Boluoke® (lumbrokinase) is the only fully researched oral fibrinolytic supplement on the market. Besides having in vitro studies, animal studies, toxicity studies, and pharmacokinetic studies done, Boluoke® has also been put through all phases of clinical trials (including randomized double blind controlled studies) in China. Lumbrokinase has been studied as a treatment for various clinical conditions, including acute, sub-acute, and chronic conditions that are associated with the presence of hypercoagulation and hypoperfusion.
Lumbrokinase is a more potent enzyme preparation than nattokinase. One of the advantages of Boluoke® (lumbrokinase) is that it does not interfere with the clotting cascade, but instead, works by reducing fibrinogen and fibrin. Boluoke® does not affect INR or aPTT, thus is compatible with Coumadin® or heparin.
Supplement Facts / Dosing
If Boluoke® is to be taken for chronic conditions, it should be taken at the dose of 1 capsule one to three times daily 30 minutes before the meal. However, the practitioner may recommend 2 capsules three times daily for 3 to 6 weeks in conditions with severe hypoperfusion. The therapeutic dose for children (according to the manufacturer)is 1 capsule per 8Kg (about 17 pounds) per day. If the lumbrokinase is emptied out from the capsule, still try to take the powder on an empty stomach.
Please consult your physician before taking this product or any other health supplement, especially if you are on any prescription medicine, are pregnant, have bleeding risks or having surgery. People with known allergy to lumbrokinase should not take this product. Keep out of the reach of children.
Boluoke® vs. Other Lumbrokinase Products
Comparing other lumbrokinase products to Boluoke® is like comparing apples and oranges. Boluoke®’s enzymatic strength is standardized against urokinase and t-PA. The imitation products are likely just earthworm protein extract containing little pure lumbrokinase or lumbrokinase of low enzymatic strength. Some companies are making products with 230mg to 250mg of lumbrokinase per capsule and trying to quote Boluoke®’s research as their own. Boluoke®’s capsules are of 200mg in size, and contain 20mg of lumbrokinase inside each capsule. Most of these other lumbrokinase are unable to distinguish between the weight of the capsule (i.e. 250 mg) and the active lumbrokinase per capsule (Boluoke® is 20 mg).
Boluoke® is the only fully researched oral fibrinolytic supplement on the market. Besides having in vitro studies, animal studies, toxicity studies, and pharmacokinetic studies done, Boluoke® has also been put through all phases of clinical trials (including randomized double blind controlled studies) in China. Boluoke® is the only Lumbrokinase that is backed by Phase I – III clinical trials in China, the one that is first used in hospitals in China, and covered by the Chinese National Fundamental Health Insurance.
A common question we receive is about potential side effects of Boluoke®. The earthworm has been used in Traditional Chinese Medicine for a few thousand years, and is considered to be one of the safest medicines in the traditional pharmacopoeias. In one of the largest clinic trials of Boluoke® involving 16 hospitals and 1560 patients in China, the overall adverse reaction rate was 1.92% (30 cases). 0.58% had skin itching, 0.19% had skin rash, and 1.15% had nausea or diarrhea; no hemorrhage or major side effect was reported. Again, this research pertains only to Boluoke®.
It is interesting that other lumbrokinase products cite the clinical results achieved with only Boluoke®, confusing the reader into assuming that the research was done on their formulations. However, their products may be very different, and your patients may have very different results.
On the raw material market, the price of lumbrokinase can vary by up to 15 fold, and the enzymatic strengths of various Lumbrokinase also differ greatly. In addition, lumbrokinase is a preparation containing multiple enzyme fractions, and the extraction and purification method determines the composition of the various enzyme fractions. Thus different extraction methods will produce different sub-fractions of lumbrokinase. This is the reason why Boluoke® does not significantly change prothrombin time (PT) or activated partial thromboplastin time (aPTT), while other lumbrokinase sources may significantly alter PT or aPTT as shown in studies. No other lumbrokinase product can provide you with this assurance.
Boluoke® seems to be beneficial for any illness that has an accompanying hypercoagulable blood state, which has been shown to be present in many chronic illnesses. Some practitioners are also recommending Boluoke® for those who choose to be on hormone replacement therapy or birth control pills, and for those who could not tolerate standard preventative pharmaceutical drugs.
High Lp(a) in blood is a risk factor for coronary heart disease (CHD), cerebrovascular disease (CVD), atherosclerosis, thrombosis, and stroke (source: Christian Wilde (2003). Hidden Causes of Heart Attack and Stroke: Inflammation, Cardiology’s New Frontier. Abigon Press, pages 182-183).
In advanced atherosclerosis, Lp(a) is an independent risk factor not dependent on LDL. Lp(a) then indicates a coagulant risk of plaque thrombosis. Apo(a) contains domains that are very similar to plasminogen (PLG). Lp(a) accumulates in the vessel wall and inhibits binding of PLG to the cell surface, reducing plasmin generation which increases clotting. This inhibition of PLG by Lp(a) also promotes proliferation of smooth muscle cells. These unique features of Lp(a) suggest Lp(a) causes generation of clots and atherosclerosis (source: Caplice NM, Panetta C, Peterson TE, Kleppe LS, Mueske CS, Kostner GM, Broze GJ, Simari RD (2001). “Lipoprotein (a) binds and inactivates tissue factor pathway inhibitor: a novel link between lipoproteins and thrombosis”. Blood 98 (10): 2980–7).
Lp-a concentrations may be affected by disease states, but are only slightly affected by diet, exercise, and other environmental factors.
Commonly prescribed lipid-reducing drugs have little or no effect on Lp(a) concentration. Hemex Labs reviewed its records of patients with high Lp(a)and were able to show that Boluoke® promotes healthy Lp(a) levels using the following regimen:
Week 1: one cap BID
Week 2: two caps BID
Week 3: three caps BID
Week 4: two caps BID
Week 5 and beyond: one cap BID
The attending physician should closely monitor patient’s blood pressure and make necessary adjustments to other blood pressure medications and/or Boluoke®.
oceangirl (verified owner) –
Best site to get Boluoke. Quick shipping and always good to get points for the purchase to be able to use on the next purchase.
Janet K (verified owner) –
Great vitamin, lowered my Fibrinogen from over 600 to about 300, much better. My dr was pleased too. . In general I have low blood pressure so I was concerned it would lower my pressure more, but that did not happen. So I am feeling it must regulate it keeping it in a healthy range. So happy I found this vitamin and this distributor. I had to call as I had an address change and John was extremely helpful. Great company. I will continue to buy & try other vitamins from them.
Janet (verified owner) –
Love this product, lowered my Fibrinogen levels to half. I believe it also regulates my blood pressure. Great company to also work with. I recently moved and they were able to help me correct my shipping address with ease and quickly.
Geraldine combs (verified owner) –
Great product working quickly
Diane Blohowiak (verified owner) –
Since his stroke, my husband has taken this in place of blood thinners to ensure his circulation is good. It’s been highly effective and recommended by several of our naturopathic physicians. Great company!
Peg (verified owner) –
This product has relieved my foot/toe pain due to inadequate circulation from small vessel problems. I am not diabetic. Thanks for a pure product. Best site to get Boluoke.
[email protected] (verified owner) –
Great product with no side effects. Highly recommend this site. Best prices.
sjsebera (verified owner) –
My practitioner recommended this to lower my fibrinogen and it’s doing it’s job. Highly recommend it.
JK (verified owner) –
After much research, I have found Boluke Lumbrokinase to be a superior product, especially when looking for a natural way to lower fibrinogen levels. Spectrum supplements is great to work with!
HeyMom! (verified owner) –
My MD/ND suggested 2.5 years ago that I start taking Boluoke® Lumbrokinase when superficial clotting became a concern for me. It’s helped to keep my situation under control without the concerns typically associated with prescription alternatives. I was also very happy to find it for a good price on Spectrum Supplements recently. Their shipping policy and promptness are a bonus – thank you!
JOE OLIVER (verified owner) –
very good product, highest quality. very satisfied.
HeyMom! (verified owner) –
I started using Boluoke Lumbrokinase 2.5 years ago and am very pleased with the results.
annalynne (verified owner) –
I can already tell this product is helping me break up all my bio film, I have Lyme and it helps with that too.